Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents
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چکیده
منابع مشابه
4-amino bis-pyridinium derivatives as novel antileishmanial agents.
The antileishmanial activity of a series of bis-pyridinium derivatives that are analogues of pentamidine have been investigated, and all compounds assayed were found to display activity against promastigotes and intracellular amastigotes of Leishmania donovani and Leishmania major, with 50% effective concentrations (EC50s) lower than 1 μM in most cases. The majority of compounds showed similar ...
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The in vitro activity on Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes of 25 semisynthetic terpenoid derivatives has been evaluated. These compounds were obtained through chemical modifications of the major components of Euphorbia resinifera (alpha-euphol and alpha-euphorbol) and Euphorbia officinarum (obtusifoliol and 31-norlanosterol). Leishmaniasis and Chagas' disease...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2016
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2016.04.047